Influence of Josephson current second harmonic on stability of magnetic flux in long junctions

We study the long Josephson junction (LJJ) model which takes into account the second harmonic of the Fourier expansion of Josephson current. The dependence of the static magnetic flux distributions on parameters of the model are investigated numerically. Stability of the static solutions is checked by the sign of the smallest eigenvalue of the associated Sturm-Liouville problem. New solutions which do not exist in the traditional model, have been found. Investigation of the influence of second harmonic on the stability of magnetic flux distributions for main solutions is performed.Comment: 4 pages, 6 figures, to be published in Proc. of Dubna-Nano2010, July 5-10, 2010, Russi

A molecular approach towards tethered bilayer lipid membranes: synthesis and characterization of novel anchor lipids

Tethered bilayer lipid membranes (tBLMs) are a promising model system for the natural cell membrane. They consist of a lipid bilayer that is covalently coupled to a solid support via a spacer group. In this study, we developed a suitable approach to increase the submembrane space in tBLMs. The challenge is to create a membrane with a lower lipid density in order to increase the membrane fluidity, but to avoid defects that might appear due to an increase in the lateral space within the tethered monolayers. Therefore, various synthetic strategies and different monolayer preparation techniques were examined. Synthetical attempts to achieve a large ion reservoir were made in two directions: increasing the spacer length of the tether lipids and increasing the lateral distribution of the lipids in the monolayer. The first resulted in the synthesis of a small library of tether lipids (DPTT, DPHT and DPOT) characterized by 1H and 13C NMR, FD-MS, ATR, DSC and TGA. The synthetic strategy for their preparation includes synthesis of precursor with a double bond anchor that can be easily modified for different substrates (e.g. metal and metaloxide). Here, the double bond was modified into a thiol group suitable for gold surface. Another approach towards the preparation of homogeneous monolayers with decreased two-dimensional packing density was the synthesis of two novel anchor lipids: DPHDL and DDPTT. DPHDL is “self-diluted” tether lipid containing two lipoic anchor moieties. DDPTT has an extended lipophylic part that should lead to the preparation of diluted, leakage free proximal layers that will facilitate the completion of the bilayer. Our tool-box of tether lipids was completed with two fluorescent labeled lipid precursors with respectively one and two phytanyl chains in the hydrophobic region and a dansyl group as a fluorophore. The use of such fluorescently marked lipids is supposed to give additional information for the lipid distribution on the air-water interface. The Langmuir film balance was used to investigate the monolayer properties of four of the synthesized thiolated anchor lipids. The packing density and mixing behaviour were examined. The results have shown that mixing anchor with free lipids can homogeneously dilute the anchor lipid monolayers. Moreover, an increase in the hydrophylicity (PEG chain length) of the anchor lipids leads to a higher packing density. A decrease in the temperature results in a similar trend. However, increasing the number of phytanyl chains per lipid molecule is shown to decrease the packing density. LB-monolayers based on pure and mixed lipids in different ratio and transfer pressure were tested to form tBLMs with diluted inner layers. A combination of the LB-monolayer transfer with the solvent exchange method accomplished successfully the formation of tBLMs based on pure DPOT. Some preliminary investigations of the electrical sealing properties and protein incorporation of self-assembled DPOT and DDPTT-based tBLMs were conducted. The bilayer formation performed by solvent exchange resulted in membranes with high resistances and low capacitances. The appearance of space beneath the membrane is clearly visible in the impedance spectra expressed by a second RC element. The latter brings the conclusion that the longer spacer in DPOT and the bigger lateral space between the DDPTT molecules in the investigated systems essentially influence the electrical parameters of the membrane. Finally, we could show the functional incorporation of the small ion carrier valinomycin in both types of membranes

SERUM GLYCOPROTEINS IN RHEUMATIC CHILDREN

No abstract

Modeling judgment of sequentially presented categories using weighting and sampling without replacement

In a series of experiments, Kusev et al. (Journal of Experimental Psychology: Human Perception and Performance 37:1874–1886, 2011) studied relative-frequency judgments of items drawn from two distinct categories. The experiments showed that the judged frequencies of categories of sequentially encountered stimuli are affected by the properties of the experienced sequences. Specifically, a first-run effect was observed, whereby people overestimated the frequency of a given category when that category was the first repeated category to occur in the sequence. Here, we (1) interpret these findings as reflecting the operation of a judgment heuristic sensitive to sequential patterns, (2) present mathematical definitions of the sequences used in Kusev et al. (Journal of Experimental Psychology: Human Perception and Performance 37:1874–1886, 2011), and (3) present a mathematical formalization of the first-run effect—the judgments-relative-to-patterns model—to account for the judged frequencies of sequentially encountered stimuli. The model parameter w accounts for the effect of the length of the first run on frequency estimates, given the total sequence length. We fitted data from Kusev et al. (Journal of Experimental Psychology: Human Perception and Performance 37:1874–1886, 2011) to the model parameters, so that with increasing values of w, subsequent items in the first run have less influence on judgments. We see the role of the model as essential for advancing knowledge in the psychology of judgments, as well as in other disciplines, such as computer science, cognitive neuroscience, artificial intelligence, and human–computer interaction

Entrainment and Control of Bacterial Populations: An in Silico Study over a Spatially Extended Agent Based Model

This is the author accepted manuscript. The final version is available from American Chemical Society via the DOI in this record.We extend a spatially explicit agent based model (ABM) developed previously to investigate entrainment and control of the emergent behavior of a population of synchronized oscillating cells in a microfluidic chamber. Unlike most of the work in models of control of cellular systems which focus on temporal changes, we model individual cells with spatial dependencies which may contribute to certain behavioral responses. We use the model to investigate the response of both open loop and closed loop strategies, such as proportional control (P-control), proportional-integral control (PI-control) and proportional-integral-derivative control (PID-control), to heterogeinities and growth in the cell population, variations of the control parameters and spatial effects such as diffusion in the spatially explicit setting of a microfluidic chamber setup. We show that, as expected from the theory of phase locking in dynamical systems, open loop control can only entrain the cell population in a subset of forcing periods, with a wide variety of dynamical behaviors obtained outside these regions of entrainment. Closed-loop control is shown instead to guarantee entrainment in a much wider region of control parameter space although presenting limitations when the population size increases over a certain threshold. In silico tracking experiments are also performed to validate the ability of classical control approaches to achieve other reference behaviors such as a desired constant output or a linearly varying one. All simulations are carried out in BSim, an advanced agent-based simulator of microbial population which is here extended ad hoc to include the effects of control strategies acting onto the population.The authors declare no competing interests. We thank Dr. Nigel J. Savery at the University of Bristol for useful discussions around the subject of GRNs and for his help in developing the original ABM model. We also wish to thank Dr Gianfranco Fiore at the University of Bristol and the anonymous reviewers for reading the revised manuscript carefully and providing insightful comments that led to a consistent revision of the original manuscript. P.M. was supported by EPSRC Grant EP/E501214/1 and K.T.-A. by EPSRC Grant EP/I018638/1. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. This work was carried out using the computational facilities of the Advanced Computing Research Centre, University of Bristol, http://www.bris.ac.uk/acrc/

Relaxation oscillations and canards in the Jirsa–Kelso excitator model: global flow perspective

This is the author accepted manuscript. The final version is available from Springer via the DOI in this record.Fenichel’s geometric singular perturbation theory and the blowup method have been very successful in describing and explaining global non-linear phenomena in systems with multiple time-scales, such as relaxation oscillations and canards. Recently, the blowup method has been extended to systems with flat, unbounded slow manifolds that lose normal hyperbolicity at infinity. Here, we show that transition between discrete and periodic movement captured by the Jirsa-Kelso excitator is a new example of such phenomena. We, first, derive equations of the Jirsa-Kelso excitator with explicit time scale separation and demonstrate existence of canards in the systems. Then, we combine the slow-fast analysis, blowup method and projection onto the the Poincar´e sphere to understand the return mechanism of the periodic orbits in the singular case, € = 0.KT-A gratefully acknowledges the financial support of the EPSRC via grant EP/N014391/1. This work was supported by The Higher Committee For Education Development in Iraq (HCED) and the University of Mosul

Changing frames of obesity in the UK press 2008–2017

Obesity is a persistently newsworthy topic for the UK press and in recent years levels of coverage have increased. In this study, we examine the ways in which obesity has been framed by the press over a ten-year period (2008–2017), focussing both on areas of stability and change. The analysis is based on a ~36 million-word database of all UK newspaper articles mentioning the words ‘obese’ or ‘obesity’ published within this time frame and draws upon techniques from corpus linguistics – a collection of computational methods for examining recurrent linguistic patterns in large bodies of language data. Our analysis shows that, over time, obesity is represented increasingly as a biomedical problem that is both caused and should be prevented by individual action. Meanwhile, focus on wider environmental determinants of health, including the role of Government and the food industry, decreases over time. In the paper, we situate these trends within the wider context of UK society and argue that they both represent the increasing dominance of neoliberal models of health but also have the potential to contribute to weight stigma and the blaming of individuals. Accordingly, it is argued that the press should seek greater balance in its reporting of the potential causes of and solutions to obesity, as well as closer alignment with scientific evidence. By doing so, the press could begin to report on obesity in a way that raises useful public awareness around the topic and which challenges some of the stigma that currently attends to this social justice issue